Key research contact details for individuals working across the BRC in the fields of dementia and neurodegenerative disorders.
Research in the development and application of molecular imaging probes, in particular for the in vivo imaging technique of positron emission tomography.
Theme lead for the Evaluation and Implementation team and leads a programme creating a registry of dementia patients for future research and analysis.
To relate the neuropsychological and behavioural profiles of degenerative dementias, such as Alzheimer's disease and frontotemporal dementia, to regional brain damage through neuroimaging (MRI and PET) and histopathological analysis.
John O' Brien, Foundation Professor of Old Age Psychiatry, University of Cambridge
His research interests include the application of neuroimaging as a biomarker for dementia, especially dementia with Lewy bodies, clinical trials and the neurobiology of late life depression.
My research interests span the areas of cognitive neuroscience, behavioural neuroscience and psychopharmacology. My work focuses on functions of the frontal lobes of the brain and their connections with other regions, including the so-called brain reward systems in the striatum and the limbic system. These brain systems are relevant to such neuropsychiatric and neurological disorders as Parkinson's and Huntington's diseases, frontal dementia, schizophrenia, depression, drug addiction, obsessive-compulsive disorder and attention deficit/hyperactivity disorder, as well as frontal lobe injury.
Characterisation and optimisation of prefrontal cortical functions in health and disease.
Theme lead for the Genomics theme within the BRC. Research interests include understanding the biology of diseases associated with protein misfolding and intracellular aggregation, using Huntington’s disease (HD) as a paradigm.
My research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments.
Theme lead for the Infection, Immunity and Inflammation theme. The immune system has evolved to defend us from infection, but defects in the regulation of immunity can give rise to autoimmune disease. We have two inter-related research programmes aimed at understanding how defective immune regulation impacts on human disease.