Highlights
Enhancing Therapeutic Cancer Vaccines by Attacking the Tumoral Stromal Cell (Fearon)
Therapeutic cancer vaccines are ineffective even though they cause expansion of tumor 'specific T cells, because these T cells are inhibited by the tumor stromal microenvironment in both humans and mice. The Fearon lab depleted stromal cells expressing fibroblast activation protein-alpha (FAP), which are found in all human carcinomas, by administering diphtheria toxin (DT) to a mouse transgenic for the human DT receptor driven by fap transcriptional regulatory elements. This caused frank necrosis of LL2/OVA tumors, supporting the proposed detrimental role for the FAP+ cell in the response to therapeutic vaccines ' work now in press with Science.
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