Imaging - Recent highlights

New PET-CT System

The new PET-CT System has provided a step change particularly facilitating experimental therapeutic trials in Oncology and other themes.

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The new PET-CT System has provided a step change particularly facilitating experimental therapeutic trials in Oncology and other themes. Last year there were five trials planned, this year there are 26 in process covering multiple themes, including oncology, neuroscience, cardiovascular and metabolism. Radiochemistry support for novel ligands remains challenging in the current financial and regulatory climate but increasingly studies with non-FDG ligands are being performed.

  • PET scanner

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Pre-clinical/Molecular Imaging

In keeping with our originally stated BRC aims we have built upon our collaborations and investment with preclinical imaging groups (locally with CRUK/CRI-Brindle, internationally with Stanford-Gambhir).

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In keeping with our originally stated BRC aims we have built upon our collaborations and investment with preclinical imaging groups (locally with CRUK/CRI-Brindle, internationally with Stanford-Gambhir).

This year two of our faculty have successfully demonstrated the impact of radiologists at different career stages moving between bedside and bench developing novel techniques with translational potential for the future (8-10).


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Novel techniques/technology

There has been further development of MR real-time techniques and 3D image navigation with a patented controller device. This is now a 3rd generation design being commercialised with Cambridge Enterprise.

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There has been further development of MR real-time techniques and 3D image navigation with a patented controller device. This is now a 3rd generation design being commercialised with Cambridge Enterprise.

We are developing techniques to overcome problems related to DCE-MRI measurements at 3T that will help facilitate future oncology and other trials. This includes a novel dual echo single heart beat saturation preparation perfusion sequence and strategies for T1 mapping and managing B1 inhomogeneity problems.


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Experimental Studies

A wide range of experimental studies has been undertaken utilising more sophisticated in-house optimised imaging biomarkers including both Ultrasound and MR based elastography, as well as Dynamic contrast enhanced DCE-MRI, Diffusion weighted DW-MRI, Pulse Wave Velocity MR-PWV, MRS and MR-R2*...

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A wide range of experimental studies has been undertaken utilising more sophisticated in-house optimised imaging biomarkers including both Ultrasound and MR based elastography, as well as Dynamic contrast enhanced DCE-MRI, Diffusion weighted DW-MRI, Pulse Wave Velocity MR-PWV, MRS and MR-R2* measurements across a range of tumour types, both for prediction and response assessment.

An initial evaluation of MR Fluoroscopy for neonatal vesico-ureteric reflux has been completed. BRC funded studies of CT perfusion measurements in liver transplantation and a PET Fluoride comparative study for detection of renal bone metastases are planned. Novel MR and PET based biomarkers for significant carotid and aortic diseases continue to be studied.


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Clinical Impact Studies

This year has seen previous radiology publications cited in guidelines for breast cancer (www.nice.org.uk) prostate cancer (www.uroweb.org) & pleural procedures. Related current studies in breast cancer screening and...

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This year has seen previous radiology publications cited in guidelines for breast cancer (www.nice.org.uk) prostate cancer (www.uroweb.org) & pleural procedures. Related current studies in breast cancer screening and evaluation of carotid artery disease have been completed. More than 50 Oncology trials using CT,RECIST measurements are currently active.


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