Research Themes

02. Cardiovascular - Contact Details

Theme Lead

Professor Martin Bennett

Theme Co-Lead

Dr Willem Ouwehand

Other Key Contacts

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Highlights Vulnerable Plaque Imaging The cardiovascular PET programme examines non-invasive measurement of inflammation, hypoxia and other markers of high-risk atherosclerotic plaque disease. The BRC has funded a trainee vascular surgeon who is supervising 2 ongoing translational research studies. One prospective study is investigating the determinants of aortic aneurysm expansion over a 3-year period, hypothesising that inflammation, hypoxia or neovascularisation detected by PET/CT or MRI at baseline is predictive of future aneurysm expansion. Read more...

Highlights

Biomechanical characteristics of bone implants and bone and cartilage graft materials

The Orthopaedic Research Unit has continued to make strong progress in translational medicine. We have characterised in detail the mechanical response of morcellised bone graft combined with hydroxyapatite graft substitute and its effect on femoral cortical strain and implant stability. This work has provided good evidence for the use of this approach to improve the biomechanical properties of the graft and to ameliorate problems of bone graft supply. This combination of bone graft and graft substitute has been evaluated in impaction grafting of the acetabulum and has resulted in good stability and graft incorporation at a mean follow up time of 5 years.

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Research Themes

02. Cardiovascular - Contact Details

Highlights

Biomechanical characteristics of bone implants and bone and cartilage graft materials