- Frank AR, Dermot PB, McGovern'et al. ' and Parkes M, 2010. Genome-Wide Meta-Analysis Increases to 71 the Number of Confirmed Crohn's Disease Susceptibility Loci. Nature Genetics. In Press
- Kraman M, Bambrough PJ, Arnold JA, Roberts EW, Magiera L, Jones JO, Gopinathan A, Tuveson DA and Fearon, DT. 2010. Suppression of anti-tumor immunity by Fibroblast Activation Protein-a-expressing stromal cells. Science. In press.
- Szczepura KR, Ruparelia P, Solanki CK, Balan KK, Newbold P, Summers C, Chilvers ER, Peters AM. Measuring whole body neutrophil re-distribution using a dedicated whole body counter and ultra-low doses of 111Indium (whole body counting). European Journal of Clinical Investigation 2010; in press.
- Jones RB, Cohen Tervaert JW, Hauser T, Luqmani R, Morgan MD, Peh CA, Savage CO, Segelmark M, Tesar V, van Paasen P, Walsh D, Walsh M, Westman K and Jayne DR, 2010. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. The New England Journal of Medicine, 363:211-220.
- McKinney EF, Lyons PA, Carr EJ Hollis JL, Jayne DR, Willcocks LC, Koukoulaki M, Brazma A, Jovanovic V, Kemeny DM, Pollard AJ, MacAry PA, Chaudhry AN and Smith K. 2010. A CD8(+) T cell transcription signature predicts prognosis in autoimmune disease. Nature Medicine, 16(5):586-91.
- Craddock N, Hurles ME, Cardin N, 'et al. ', Parkes M, Rahman N, Todd JA, Samani NJ and Donnelly P (Wellcome Trust Case Control Consortium). 2010. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 464(7289):713-20.
- Willcocks LC, Lyons PA, Clatworthy MR, Robinson JI, Wanling Y, Newlande SA, Plagnol V, McGovern N, Condliffe A, Chilvers ER, Adu D, Jolly EC, Watts R, Lau YL, Morgan AW, Nash G and Smith KGC. Copy number of FcyRIIB is associated with protection against malaria but susceptibility to Systemic Lupus Erythematosus. 2010. Proc Natl Acad Sci USA 107:7881-7885.
- Nadala EC, Goh BT, Magbanua JP, Barber P, Swain A, Alexander S, Laitila V, Michel CE, Mahilum-Tapay L, Ushiro-Lumb I, Ison C and Lee HH. 2010. Performance evaluation of a new rapid urine test for Chlamydia in men: Prospective cohort study. British Medical Journal, July 28, 339: b2655. doi: 10.11356/bmj.b2655.
- Clatworthy MR, Watson CJE, Plotnek G, Bardsley V, Chaudhry AN, Bradley JA and Smith KGC. B cell depleting induction therapy and acute cellular rejection. 2009. The New England Journal of Medicine, 360: 2683-2685
- Cheung W, Gill M, Esposito A, Kaminski CF, Courousse N, Chwetzoff S, Trugnan G, Keshavan N, Lever A and Desserlberger U., 2010. Rotaviruses associate with cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication. Journal of Virology, 4: 6782-98.
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Highlights
Translational medicine and autoimmunity (Smith, Jayne)
The BRC has funded a bio-informatics post to support the biomarker discovery programme run by the Smith laboratory, which has resulted in the discovery of a prognostic biomarker which has been patented, published in Nature Medicine, and is soon to enter clinical trials. In addition to the initial findings made in SLE and vasculitis, these findings have been replicated in Inflammatory Bowel Disease and transplantation.
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