Evaluating novel targets for therapeutic intervention in tissue injury
Research relating to the role of TNF and its receptors has demonstrated the independent regulation and differential functions of TNFRs in myocardium, consistent with TNFR1-mediated tissue injury and cell death and TNFR2-mediated repair. These results are being translated into potential novel therapeutic approaches to reducing graft loss through a number of strategies. Peptides which may act as TNF receptor selective agonists and antagonists are being designed based on existing knowledge of TNF-TNF receptor interactions, in collaboration with Professor Shankar Balasubramanian Department of Chemistry, University of Cambridge. These peptides are currently being tested in receptor binding assays.